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Temporal trends in hyperuricaemia in the Irish health system from 2006-2014: A cohort study

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Ultra-performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) enables precise quantification of structurally diverse BA species (175, 176), facilitating detailed characterization of the bile acid-ome. The emerging field of reverse metabolomics further accelerates the discovery of novel bioactive BA derivatives, including previously unannotated microbial metabolites, directly detected in human-derived biospecimens (82)

Mitochondrial cristae are formed by multiple folds of the inner mitochondrial membrane extending into the mitochondrial matrix (Pape et al., 2020), They include crista junctions, which connect the cristae membranes to the inner boundary membrane, and cristae tips at the distal ends of the cristae membranes (Kondadi et al., 2020)