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Intracellular iron accumulation is significantly facilitated by diminished expression of ferroportin (FPN), the sole confirmed iron exporter ( - ) constitutes the initial ferroptotic signal
10.1182/blood-2007-07-102335 Blood 130 SoragniE.MiaoW.IudicelloM.JacobyD.De MercantiS.ClericoM.et al (2014)
Therapeutic cells via functional modification: influence of molecular properties of polymer grafts on in vivo circulation, clearance, immunogenicity, and antigen protection
S1AS1C), suggesting that even minimal production of GSH can maintain homeostatic processes in the body
In combination, the addition of IL-6 appears to counteract the changes to neural function induced by low concentrations of TNF-, while at high concentrations of TNF- the addition of IL-6 had little to no effect
