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These cover innovative formulation strategies, chemical coupling with hydrophobic ligands or nanoparticles that exhibit targeted affinities, modifications of amino acid backbone, as well as the utilization of enzyme inhibitors, permeation enhancers, and mucoadhesive polymers [94]

Nat Commun (2016) 28:12015

Ethics declarations The experimental protocol followed the guidelines of the Declaration of Helsinki, and it was approved by the University of Granada Institutional Review Board (IRB approval, 438/CEIH/2017)

By selectively inhibiting NNMT, 5-Amino-1MQ preserves SAM and NAD+ precursors, creating a metabolic environment that favors fat oxidation over fat storage
