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The -chain aggregates could produce reactive oxygen species, leading to oxidative stressinduced red blood cell (RBC) senescence [3].The basic clinical symptom of -thalassemia major is chronic anemia, which reduces the number of RBCs and hemoglobin (Hb) content, resulted from hemolysis and a deficiency in Hb production When RBCs are destroyed within the vascular compartment, Hb escapes into the plasma, dimerizes, and is rapidly bound by the serum protein haptoglobin (Hp)

Therefore, the above studies suggest that vascular ROS promotes plaque stability by modulating the expression and activities of MMPs

Once reconstituted, it is sensitive to degradation, and repeated freeze-thaw cycles should be avoided to maintain structural integrity

Common non-clinical applications include analytical reference work and documented research workflows