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Foreign DNAs (which are not methylated in this manner) that are introduced into the cell are degraded by sequence-specific restriction enzymes and cleaved
Additionally, multiobjective optimization methods such as reinforcement learning 271 and Bayesian optimization 272 can help to create formulations that optimize aerosol performance, mucus penetration and cellular uptake at the same time
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Non-viral delivery of nucleic acids: Insight into mechanisms of overcoming intracellular barriers
