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Sign 6: Feeling Lightheaded or Slightly Breathless Feeling faint when standing or breathless after mild activity might signal a B12 issue

JAMA 305, 13481349.Google Scholar Scarmeas, N, Anastasiou, CA & Yannakoulia, M

Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction

Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing

Expression of mt-roGFP in park 13 tyrosine hydroxylase positive neurons showed significantly reduced mitochondrial ROS accumulation under Sp treatment as compared to untreated ones, highlighting potential mitochondrial recovery and prevention of oxidation induced cell death in dopamine producing neurons (Fig