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[online] European journal of clinical nutrition

Efficacy of NNMT inhibitor 5-amino-1MQ in diet-induced obese (DIO) mice 17-week old, male DIO C57Bl/6 mice that have been fed high-fat diet (HFD) for 11 weeks (starting at week 6) were purchased from Jackson Labs (Jackson Laboratory

Department of Primary Industries and Regional Development

Key finding: NNMT inhibition increased intracellular NAD+ by 1.4-fold and activated SIRT1/SIRT3 fat oxidation pathways direct link to the longevity-associated sirtuin cascade