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The review synthesized findings from cell-culture experiments (human dermal fibroblasts, keratinocytes, irradiated fibroblasts), animal models (rats, mice, pigs, dogs), and human cosmetic-science studies of topical formulations

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To assess binding of FITC-z13 to CNGB3, we transfected HeLa cells with a mammalian expression vector encoding a CNGB3MYC fusion protein or with control empty vector

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Early engagement with the FDA, robust validation of product claims, and alignment with regulatory expectations are essential to avoid enforcement actions