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It remains unclear to what extent the improved graft integration is a consequence of attenuated reactive gliosis or of an altered Notch signaling between resident astrocytes and neural grafts or grafted neural stem/progenitor cells

[41] showed that edaravone dexborneol effectively suppressed nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) inflammation-induced activation of microglial pyroptosis in experimental ischemic stroke through NF-B/NLRP3/gasdermin D (GSDMD) signaling pathway using transient MCAO (tMCAO) mouse model in vivo and oxygen-glucose deprivation (OGD) BV2 cell model in vitro

Neurosci Lett 1992;142:12830

J.ChristiansenE.TikhonovaI

The whitening agents can penetrate deeper into the skin layers so there are fewer chances of them getting whiter