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Unlike the known biochemical and nutritional effects of geometric isomers, there is little information about the biological effects of positional isomers and for the majority of them these effects are considered as not relevant, except for some conjugated structures, such as conjugated linoleic acid (C18:2, 9, 11, CLA), a geometric and positional isomer of the most common linoleic acid, for which it has been attributed various health properties, especially those related to anti-inflammatory and lipolytic actions, but up to date the scientific evidence for these properties are considered insufficient [47]

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For example, the somatic NF1 mutation of sporadic MPNST is similar to NF1-associated MPNST [44]

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