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Cancer treatments significantly elevate OS through multiple mechanisms: chemotherapeutic agents, particularly alkylating agents and platinum compounds, generate excessive ROS directly damaging sperm DNA and membranes (87, 88), while radiation therapy induces both acute and chronic OS states in testicular tissue, leading to prolonged spermatogenic dysfunction (95)

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Looking at the Clinical Trial Database, there are no fewer than 61 trials underway worldwide using LDN including some in ME/CFS, FM, and various painful autoimmune disorders

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