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Hui reports the development of encephalopathy in a woman who received a GBCA for MRI (Hui and Mullins 2009)

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463 Despite the drawbacks, new possibilities have arisen within the past decade to developing next generation gold agents beyond auranofin, the gold standard. Progressively, evidence of (i) the importance of gold in medicine, (ii) the success of gold in clinical trials (14 to date), (iii) the determination and creativity of scientists, and (iv) state-of-the-art technologies will propel next generation gold agents into clinical use