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Such neurons fire quickly during wakefulness periods, fire very slowly over relaxation/tiredness periods, and stop firing entirely in rapid eye movement sleep (REM) and non-rapid eye movement (NREM) sleep [108,109]

Shown below are two figures (Figures 5 and 6) summarizing the sequential steps recommended in managing and treatingpersons chronically infected with hepatitis C for whom treatment is considered to be clearly appropriate