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In summary, -LA supplementation enhanced cellular apoptosis via increased ROS levels, HIF-1 expression, and JNK/caspase-3 signaling pathway in advanced human PCa cell lines

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Methods in this observational study, we applied a comprehensive multi-omics approach to dissect the molecular and metabolic alterations underlying late-stage lipedema

Written by registered dietitian, Detrick Snyder, MPH, RDN

While redox homeostasis via enhanced glutathione production is commonly associated with the normal physiological role of NRF2, collectively our results suggest that NRF2-dependent cancer cell growth does not require this enhanced glutathione production.