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The honest answer, based on the available research, is that the effect is real and directionally consistent with the physiology, but modest under ordinary circumstances not the dramatic swing implied by many unsourced blog claims

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B12-downregulated genes in this group were related to positive regulation of transcription by RNA polymerase II, processing and transport of mRNA, mRNA splicing, cellular response to DNA damage stimulus, activation of innate immune response, positive regulation of IL-6 and IL-2 production, T-cell differentiation in thymus, histone modification, viral transcription and DNA conformational change