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Nature 445, 666670
These mutant mice displayed constitutively active NF-B, which led to a prominent increase in macrophages/microglia, T cells, and key proinflammatory mediators (45)
Activation of KORs (expressed in the spinal dorsal horn) can block the release of excitatory neurotransmitters, including glutamate and substance P, which in turn attenuates nociceptive signaling [62]
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[DOI] [PubMed] [Google Scholar] [164].van den Berg CJ, Garfinkel D, A simulation study of brain compartments
