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Steroid-sparing treatments, including immunosuppressive agents and biologics such as hydroxychloroquine, can reduce dependence on corticosteroids and limit their associated damage (109)

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Thus, TrxR1/Gsr-null yeast are non-viable [89, 90] as are colonies coincidentally lacking Gsr and both thioredoxins (Trx1 and Trx2) [91]

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