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Figure 3 2.1.2 TCM approaches for managing metabolic risks and diabetic complications 2.1.2.1 Stimulation of insulin secretion Several TCM herbs have been reported to promote insulin release, primarily through the modulation of the PI3K/AKT signaling pathway, which plays a key role in glucose uptake, glycogen synthesis, and gluconeogenesis

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Heparin hepatotoxicity involved direct toxicity, hepatocyte membrane modification and immune-mediated hypersensitivity reaction [114]