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One-way ANOVA showed significant differences between the groups in terms of age ( p = 0.001), hence age was included as a covariate in between group comparisons of metabolite concentrations

The authors of the trial did not consider the effect on stroke outcomes to be valid because they opined that the pathogenic mechanisms underlying myocardial infarction and stroke were essentially the same and therefore an effect of homocysteine-lowering should have been observed for both vascular outcomes

10.1093/nar/gku176 (2014)

From this perspective, the hypothesis that bromelain acts as a radiosensitizer and radioprotector becomes suggestive

Li N, Guo Y, Gong Y, Zhang Y, Fan W, Yao K, et al