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As a result, patients on long-term opioid therapy often experience more pain, even at the same or higher doses of opioids, necessitating further increases in dosage that perpetuate the cycle of hyperalgesia

359 Furthermore, the enzymes responsible for disulfide bond isomerization, PDI in eukaryotes 381 and DsbC in prokaryotes, 381 can be supplemented to enable the proper formation of disulfide bonds

FIGURE 1 6.2 Exercise as core long-term management: constructing a multidimensional intervention system 6.2.1 Community and home-based rehabilitation: technology-enabled remote rehabilitation systems Using mobile medical rehabilitation platforms is safe and increasingly popular (Diamond et al., 2021)

[DOI] [PubMed] [Google Scholar] Carr A, Frei B