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Available online at: Greil R., Greil-Ressler S., Weiss L., Schnlieb C., Magnes T., Radl B., et al

doi: 10.1212/01.WNL.0000132644.52613.FA

Additionally, individuals on long-term proton pump inhibitors (PPIs) or metformin therapy are at increased risk due to drug-related malabsorption

In this article, we shall review and discuss the current status of glutathione as a skin lightening agent and address the sundry unanswered queries regarding the dosage, duration of use and longevity of accrued effects based on clinical evidence and recent insights into its antimelanogenic mechanism

In addition, the docking scoring function mainly evaluates static binding affinity, which makes it tough to accurately simulate the complex physiological environment in living organisms (such as solvation effects, entropy changes, etc.), which might result in false positives in experiments for molecules that are predicted to bind well (Gioia et al., 2017