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This combination is appropriate for chronic trigger points that haven't responded to lidocaine alone, trigger points near inflamed tendons or bursae, and patients with underlying inflammatory conditions

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Trafton JA, Abbadie C, Marek K, Basbaum AI: Postsynaptic signaling via the [mu]-opioid receptor: Responses of dorsal horn neurons to exogenous opioids and noxious stimulation
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