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Metal oxide nanoparticles: evidence of adverse effects on the male reproductive system
[3] Certain peptides, such as angiotensin II, basic fibroblast growth factor-2, and parathyroid hormone-related protein, can also interact with intracellular receptors in the cytoplasm or nucleus through an intracrine mechanism

& Gartner, Z

This is a build-up of plaque inside the arteries which increases the risk of heart attack and stroke

Both groups appear to be throwing just about every compound they can think of up the noses of their laboratory rodent models, and some compounds are making it to human trials as well
