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[0222] Embodiment 215: A method of treating a mammal with a cancer comprising cells that express ALPP and/or ALPPL2, or a region of ALPP and/or ALPPL2 bound by antibody M25AD, M25ADX and/or M25, said method comprising: administering to a mammal an effective amount of a cell genetically modified to express a chimeric antigen receptor (CAR) according to any one of embodiments 201-205