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4,5 Notably, emerging evidence suggests that transcriptional and epigenetic mechanisms also influence these processes, thus supporting their consideration in the broader regulatory landscape of autophagy

Ethics declarations Competing interests J.M.J., J.F.H., I.B., J.M.M., B.H., K.P., J.J.F., S.S., A.S., S.L., K.R

These medical disorders are probably caused by the extensive expression of angiotensin-converting enzyme 2 (ACE2) receptor (i.e., facilitator of SARS-CoV-2 entering cells) and many dysfunctional biological processes (such as chronic inflammation, endocrine disorders, immune disorders, tissue damage, tissue hypoxia, dysbacteriosis, coagulation and endothelial abnormalities, and neurological signal dysfunction) (Szabo et al., 2023

Cytokines such as IL-1 and TNF-, which are pivotal in inflammation, also serve as sleep-regulating molecules, promoting NREM sleep at physiological levels but contributing to sleep fragmentation when chronically elevated (Zielinski and Gibbons, 2022)