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While animal studies consistently demonstrate beneficial effects across diverse injury models and tissue types, the absence of adequately powered, controlled human clinical trials prevents definitive conclusions about efficacy in human disease

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Ongoing clinical trials are exploring other applications of CD38 antibody containing IgA nephropathy (NCT05065970) and even metastatic renal cell carcinoma (NCT03473730).The study( NCT05704400 )is researching the effectiveness of the combination therapy of CD20 monoclonal antibody and daratumumab monoclonal antibody in the treatment of pediatric multidrug-resistant nephrotic syndrome ( Table 2 )

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