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Loss of the normal hepatocytic architecture, vacuoles, degeneration of hepatocytes with pyknotic nuclei (black square& black arrow), fibrosis and congestion around the portal area (black circle), dilation and congestion of portal vein (blue dotted arrow), congestion in hepatocytes and blood sinusoids (black dotted arrow), bi-nucleated hepatocyte (green dotted arrow) were seen in the photomicrograph of T.S in the liver of Tadalafil-treated rabbits [Fig 2C]

Trial data have shown weight reductions of up to approximately 22% in clinical studies

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10.3389/fpsyt.2020.561998 165 ZarezadehM.MahmoudinezhadM.HosseiniB.KhorraminezhadL.RazaghiM.AlvandiE.et al (2023)

TID, three times a day