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By contrast, incubation of Neuro-2a cells with SAMe enhanced PP2A methylation, led to the beneficial accumulation of dephosphorylated tau, and increased secretion of neuroprotective -secretase-cleaved APP fragments [173]

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Our findings show the effect of depletion of existing intracellular GSH and inhibition of GSH biosynthesis with a BSO-based peptide derivative, which provides a new strategy for in situ construction of selective and efficient nanomedicine for intracellular GSH regulation and tumor inhibition

ZO-1, a key tight junction protein, was severely damaged in the RT group, while the EGCG-Zn group significantly restored ZO-1 continuity (Figs

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