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While EAE models have offered valuable insight into adaptive immune responses, demyelination, and axonal damage in MS, they fall short in replicating the full spectrum of human MS pathology, particularly the disease's onset and heterogeneity (Figure 5)

However, only one study ( Reference Bates 27 ) has reported that riboflavin deficiency increased MDA levels in the lens but did not affect MDA content in the liver in rats

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Atherosclerosis 208, 228233