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Feeling drained, inflamed, or run down

Nguyen TT, Voeltz GK
Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling

The migraine attack as a homeostatic, neuroprotective response to brain oxidative stress: preliminary evidence for a theory
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(January 1988)
