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When grown in an arginine medium, on the other hand, there were only a few intracellular metabolites for which their concentrations were significantly changed comparing the gdh3 / gdh3 and wild-type cells, suggesting that the gdh3 / gdh3 mutant cells were in a similar metabolic state to the wild-type cells under this environmental condition (Fig

doi: 10.1186/s40580-021-00260-z 20 DHerdeKKryskoDV

Moreover, the authors suggested that the presence of AHK-Cu may have reduced the number of apoptotic dermal papilla cells

Their depletion and functional impairment, driven by a hostile degenerative microenvironment and dysregulated signaling pathways, are critical factors in disease progression

doi: 10.1016/0165-022X(88)90100-5