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[] Histopathologically, the transition from neurofibroma to MPNST is characterized by nuclear atypia, loss of neurofibroma architecture, high cellularity, and increased mitotic activity

The final label was then obtained by thresholding (Equation 16):where denotes the decision threshold

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A major upheaval occurs during and immediately after the fertilization period: the DNA of the zygote genome is thought to be rapidly de-methylated immediately postfertilization, and human in vitro fertilized IVF embryos apparently follow this scheme