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In the presence of TRP-2, dopachrome tautomerizes to yield DHI-2-carboxylic acid (DHICA), which then rapidly oxidizes and polymerizes to form DHICA-melanin by TRP-1 [19]

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Very-low-level viremia, inflammatory biomarkers, and associated baseline variables: three-year results of the randomized TANGO study

ICIs work by blocking the interactions between immune checkpoints such as CTL-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), and programmed cell death ligand-1 (PD-L1) and their ligands, which releases the inhibitory brakes of T cells and results in the robust activation of immune responses (Fig