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A recent study that investigated the effect of VCN in suppressing the progression of non-alcoholic steatohepatitis (NASH) in mice mentioned that the anti-inflammatory of VCN could be mediated by inhibition of NLRP3 inflammasome activation and hence the NF-B signaling pathway which results in a reduction in the production of pro-inflammatory cytokines 74

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106 Subsequently, TNF- operates in an autocrine manner, further activating NF-B

The interaction between them is regulated by the upstream gene called F-box only protein 8 (FBX8)

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