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The trend is real but we cannot point to one proven reason
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Blumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, Fujiwara P, Grzemska M, Hopewell PC, Iseman MD, Jasmer RM, Koppaka V, Menzies RI, OBrien RJ, Reves RR, Reichman LB, Simone PM, Starke JR, Vernon AA (2003) American Thoracic Society/Centers for disease control and prevention/infectious diseases Society of America: treatment of tuberculosis

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However, iso-coumarins can exert anti-tumor effects by continuously inhibiting the PI3K/AKT/mTOR pathway ( Current research on coumarins has identified their anticancer mechanisms through multiple signaling pathways across various cancer types
