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[PubMed: 10647754] 24
Kisspeptin Is Involved in Ovarian Follicular Development During Aging in Rats

STEP 5: long-term data The 2-year STEP 5 trial provides the most important real-world context

Citrus aurantium essential oil and its primary component, limonene, significantly prevented gastrointestinal mucosal injury in rats by increasing mucus production and maintaining basal prostaglandin E2 (PGE2) levels

This endogenous presence provides a baseline safety context
