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Even though 1 O 2 has a short half-life of about 3 s (Hatz et al., 2007), it can manage to diffuse some 100 nanometers and causes damage to wide range of targets

It makes everyday life uncertain and uncomfortable
Nunes et al., 2018

This single amino acid substitution between apoE4 and apoE3, and apoE3 and apoE2 drastically alters the functionality of apoE, resulting in isoform-specific variations in structure that modulate lipid binding, receptor binding, oligomerization propensity, and stability [38,39,40,41] (Fig
