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Further, N-Homocysteinylation of both non-histone and histone residues (by increased Hcy thiolactone) represents a post-translational modification [32] that causes also alterations in gene expression [33]
The prognostic significance of LOH 10q is well established, particularly in differentiating primary from secondary GBM
& Ou, D.-L
The absence of a specific trial doesn't negate the overwhelming body of indirect and mechanistic evidence
J Formos Med Assoc 1992
