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This review aimed at summarizing the current knowledge on the role of phthalate and non-phthalate plasticizers in thyroid dysfunction and disease, describing the major biological mechanisms underlying this relationship

doi: 10.1186/s40170-024-00337-3 16 HamanakaR

The mechanism underlying these benefits involves correcting endothelial dysfunction in aortas, where provinol improves endothelium-dependent relaxation and enhances NO bioavailability by increasing eNOS activity and reducing superoxide anion release ( In a study on hypertriacylglycerolemic rats, the pyridoindole derivative SMe1EC2 (10 mg/kg) and the natural polyphenol rutin (100 mg/kg) were found to upregulate eNOS3 expression, a crucial factor in NO production