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More recent studies have shown that regional depletion of glutamine from PDAC tumors stimulates macropinocytosis by activating EGFR/PAK signaling and supplying glutamine via degradation of extracellular proteins in lysosomes 121
[PUBMED Abstract] Pui CH, Pei D, Sandlund JT, et al.: Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
(2015) measured AAs levels in children with CD using tandem MS and compared these levels to those of HCs
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Researchers have examined SNAP-8 in the context of peptide signalling and skin surface appearance studies
