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Moreover, in contrast to vitamin B 6 deficiency, the increased atherosclerotic vascular risk associated with folate deficiency is mediated through elevation of plasma homocysteine (Robinson et al, 1998)

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After a final step consisting of an acid treatment, SPS-based cereblon PROTACs are obtained with good yields (Scheme 17) 181

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In addition, this effect may not be due to defective mitochondrial respiration but to the upregulation of glycolytic enzymes and glucose transporters (Wangpaichitr et al., 2021)

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