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Beyond direct cytokine effects, VNS helps rebalance autonomic outflow in septic shock, which can stabilize hemodynamics and protect organ function
For instance, systemic administration of iron chelators such as deferoxamine or deferasirox effectively reduces Fe + levels and lipid peroxidation but carries the risk of disrupting systemic iron metabolism, potentially causing anemia, immune dysfunction, and impaired wound healing (53, 196, 197)
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