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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Conclusion While many people can obtain sufficient B12 through a balanced diet rich in animal products, others may benefit significantly from B12 injections, especially those with dietary restrictions, absorption issues, or specific health conditions

This is particularly important for individuals with conditions that interfere with B12 absorption, such as pernicious anemia, gastrointestinal disorders like celiac disease or Crohns disease, or those who have undergone certain types of gastrointestinal surgery

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