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Previous studies have reported that individuals with type 1 diabetes exhibit deficits in cognitive flexibility, as evidenced by increased perseverative errors and set-shifting difficulties in the Wisconsin Card Sorting Test compared to healthy controls 6
the D-Nle Trp- Ile-NH-(CH 2 )5-CONH 2 analog which exhibits intermediate inhibition of dimerization, predictably has a moderate affinity for HGF and a moderate ability to inhibit HGF-dependent processes ( Figures 25, 26, 27)
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The practical result is threefold: the GHK-Cu loses its copper(II) coordination and likely its biological activity
