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Description
On one hand, KG-mediated citrate production in mitochondria is used to produce acetyl-CoA in the cytoplasm through ATP citrate lyase (ACL)

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In some cases, the harvest cell culture was treated with Benzonase endonuclease (Cat#: 101697, Merck KGaA, Darmstadt, Germany)
When the free radical concentration gets too high, DNA is damaged and cells die

Springer, 2021