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J Clin Invest (2008) 118:82938

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Beyond oxidative stress: an immunologists guide to reactive oxygen species

It is necessary to expand extensive chronic clinical trials to evaluate the long-term safety, efficacy, and optimal dosing of polyphenols, examine gene-diet and microbiota-polyphenol interactions to elucidate inter-individual variability, develop innovative delivery systems to improve bioavailability and facilitate clinical translation, and clarify potential drug interactions and safety in vulnerable populations

Conversely, the antioxidant activity of black tea kombucha did not differ significantly from unfermented black tea