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dopamine) suggesting that these extracts may be useful in ameliorating some of the effects of Parkinson disease as well as some of the behavioral effects of Huntington disease

SAMe supports production of glutathione, which is a critical antioxidant for detoxification of drugs and toxins in the liver

This mechanism involves increased expression and immunoreactivity of key proteins involved in the cholinergic neurotransmission cycle: acetylcholine transferase (ChAT), high-affinity choline transporter (CHT), vesicular acetylcholine transporter (VAChT), and muscarinic M1 receptor (M1R)

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The pro-inflammatory mediator (e.g., LPS and cytokines)-induced expression of iNOS has been shown to be suppressed by sulforaphane, such as in peritoneal macrophages [71], bone marrow-derived macrophages [72], stimulated RAW264.7 cells [89,90,91,92,93,96,97], PMBC-derived macrophages [78,99], BV2 microglial cells [110], astrocytes [116], mammary epithelial cells [130], neuroblastoma SH-SY5Y cells [161], C2C12 myoblasts [147], and vascular smooth muscle cells (VSMCs) [150]