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Coptidis Rhizoma contains a variety of alkaloids, such as berberine, coptisine, palmatine, and especially berberine

Conventional antioxidants lack such precision, often impairing essential oxidative signaling

Studies have shown that urinary OPN is superior to serum creatinine and other markers in early prediction of vancomycin-induced kidney injury (VIKI) and is effective in assessing the degree of kidney injury in combination with KIM-1 [71]

93, 94 Recent clinical data also indicates that variants of GTP cyclohydrolase I are governing NO production, autonomic activity and even cardiovascular risk