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45 By far the largest trial was the Age-Related Eye Disease Study (AREDS), a multi-centre, double-blind, placebo-controlled trial of 3647 participants with AMD with a mean follow-up of 6.3 years

A study using a three-dimensional tumour sphere model combined with CRISPR-Cas9 screening reported that Nrf2 overactivation was essential for lung tumour proliferation and survival, whereas silencing of Nrf2 predisposed spherical cells to ferroptosis, which was also consistent with clinical observations [77]

If you experience worsening fatigue, jaundice (yellowing of skin or eyes), abdominal swelling, or confusion, contact your GP urgently, as these may indicate progression of liver disease requiring medical assessment

Certificate of analysis (COA) with a batch number enabling full traceability from synthesis through to delivery

Unprocessed western blots for Extended Data Fig