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Their small, linear structures facilitate easier synthesis, high water solubility, and effective diffusion across biological barriers

EGF is bioactive but barrier-limited: the molecule does what it does only if it reaches the keratinocyte layer, and standard topical formulations deposit most of it on the stratum corneum where it has no relevant receptor

Interestingly, the expression of C3 was increased in treated astrocytes but did not reach significance (Figure 7)

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